The Protein Folding Problem

protein folding Research Focus: In my research to date I have primarily focused on the ab initio protein folding problem due to its utmost importance to human health. The problem consists of predicting the functional three dimensional structure (the native state) of a protein from its amino acid sequence. Despite the fact that the number of known protein structures continues to grow, identifying the structures of all proteins will not suffice to answer many questions related to disease, including those directly caused by protein mis-folding such as certain types of cancer, Alzheimer's, and Parkinson's diseases. Ultimately, solution to this problem will lead to efficient rational drug design enabling specific targeting of certain aspects of protein three-dimensional shape and modifications of proteins leading to desired functions.

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