DireX - Low-resolution structure refinement

DireX allows for efficient geometry-based conformational sampling of protein structures under experimental restraints. DireX combines prior structural information with experimental data through the Deformable Elastic Network (DEN) approach which drastically reduces over-fitting.

Experimental restraints which can be used in the current version are:

Electron density map (obtained e.g. from X-ray crystallography, Electron microscopy, or SAXS)
Distance restraints (e.g. from NMR or FRET experiments)

To get a first impression: Watch a movie of fitting Ca-ATPase into a 10 A electron density map.